Flow cytometry analysis of platelets with fluorescein-labeled Helix pomatia , a lectin specific for A antigen, shows that group A 1 platelets express A antigen but not group A 2. See the complete figure in the article beginning on page The absence of A antigen on A 2 platelets has important clinical implications since the transfusion of ABH incompatible platelets results in reduced platelet recovery and survival in all patients.
The clinical responses to platelet transfusions are variable and differences in platelet A antigen expression may explain some of this variability. Group O patients are often given group A platelets of unknown subgroup. Since group A 2 platelets do not express A antigen, group O patients likely respond better to A 2 platelets than A 1 platelets. These finding are especially important for hematopoietic stem cell transplantations involving donors and recipients with mismatched A and O blood groups.
It is best to transfuse these patients with platelets that do not express A antigen and that lack anti-A. Since only group A 2 platelets meet both criteria, for these patients A 2 platelets are ideal. Sign In or Create an Account. Sign In. Skip Nav Destination. Plasma acts as a transportation system for everything in the blood. About 90 per cent of plasma is water and the other 10 per cent is made up of the various materials being transported by the plasma. Plasma brings nutrients like proteins, minerals, vitamins, sugars, and fats to all parts of the body and carries away waste products.
Plasma also transports the red blood cells, which carry oxygen and carbon dioxide to and from our organs and tissues. The constant circulation of white blood cells and antibodies in the plasma allows them to go anywhere they are needed to fight invading germs; similarly, circulating platelets and clotting proteins will be activated wherever blood clots are needed. Proteins that circulate in the plasma include albumin, antibodies and clotting proteins.
Albumin is the most abundant protein in the plasma, and helps maintain fluid balance in your body by keeping water inside the blood vessels. Antibodies make up more than one-third of the protein in the plasma. Clotting proteins in the plasma are required for platelets to form blood clots. In transfusion medicine, plasma is isolated from donated whole blood. Plasma can also be selectively collected from donors using an apheresis machine. Plasma products can be stored frozen for long periods of time up to one year at Canadian Blood Services until required for a transfusion.
In transfusion medicine, proteins such as albumin, immunoglobulins and clotting factors are isolated from plasma using a fractionation process. Once fractionated those proteins can be stored freeze-dried lyophilised for long periods of time and be used to treat specific medical conditions.
What are blood groups? What is meant by a blood match? While several blood group systems are used to type your blood, ABO is the most important. Your ABO type is based on the presence or absence of two antigens A and B on the surface of red blood cells.
That leaves us with eight possible blood types:. Each of these eight types is unique. Blood types determine who you can give blood to and receive blood from.
Which type of donation is best for you is determined by your blood type, as well as patient need. Skip to content Donate Now 1 minute read Blood. Error happened. Pin It on Pinterest.
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